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Complete List of Publications


2010-present

  • Bourne JN, Chirillo MA, Harris KM (2013) Presynaptic ultrastructural plasticity along CA3->CA1 axons during LTP in mature hippocampus. J Comp Neurol, doi: 10.1002/cne.23384. [Epub ahead of print] (1MB PDF)

  • Edwards J, Daniel E, Kinney J, Bartol T, Sejnowski T, Johnston D, Harris K, Bajaj C (2013) VolRoverN: Enhancing surface and volumetric reconstruction for realistic dynamical simulation of cellular and subcellular function. Neuroinformatics, doi: 10.1007/s12021-013-9205-2 [Epub ahead of print].(1MB PDF)

  • Kuwajima M, Mendenhall JM, Lindsey LF, Harris KM (2013) Automated Transmission-Mode Scanning Electron Microscopy (tSEM) for Large Volume Analysis at Nanoscale Resolution. PLoS One, 8(3):e59573. PMCID: PMC3608656. (9MB PDF)

  • Kinney JP, Spacek J, Bartol TM, Bajaj CL, Harris KM, Sejnowski TJ (2013) Extracellular sheets and tunnels modulate glutamate diffusion in hippocampal neuropil. J. Comp. Neurology, 521:448-464. PMCID: PMC3540825. (8MB PDF) (Shared data)

  • Kuwajima M, Mendenhall JM, Harris KM (2013) Large-Volume Reconstruction of Brain Tissue from High-Resolution Serial Section Images Acquired by SEM-Based Scanning Transmission Electron Microscopy. Methods Mol Biol (Nanoimaging: Methods and Protocols), 950:253-73. (1MB PDF)

  • Kuwajima M, Spacek J, Harris KM (2013) Beyond counts and shapes: Studying pathology of dendritic spines in the context of the surrounding neuropil through serial section electron microscopy. Neuroscience, 251:75-89. PMCID: PMC3535574. (2MB PDF)

  • Harris KM, Weinberg RJ (2012) Ultrastructure of Synapses in the Mammalian Brain. Cold Spring Harb Perspect Biol., 4(5). (2.4MB PDF)

  • Cao G, Harris KM (2012) Developmental regulation of the late phase of long-term potentiation (L-LTP) and metaplasticity in hippocampal area CA1 of the rat. J Neurophysiol., 107(3):902-12. PMCID: PMC3289468. (2.5MB PDF)

  • Cui-Wang T, Hanus C, Cui T, Helton T, Bourne J, Watson D, Harris KM, Ehlers MD (2012) Local zones of endoplasmic reticulum complexity confine cargo in neuronal dendrites. Cell, 148(1-2):309-21. PMCID: PMC3266556. (2.4MB PDF)

  • Commentary on Cui-Wang et al.:
    • Lewis S (2012) Cellular neurophysiology: ER cargo confinement influences dendritic plasticity. Nat Rev Neurosci, 13(3):152-3. (300KB PDF)

  • Bowden JB, Abraham WC, Harris KM (2012) Differential effects of strain, circadian cycle, and stimulation pattern on LTP and concurrent LTD in the dentate gyrus of freely moving rats. Hippocampus, 22(6):1363-1370. PMCID: PMC3292688. (700KB PDF)

  • Bourne JN, Harris KM (2011) Nanoscale analysis of structural synaptic plasticity. Curr Opin Neurobiol., 22(3):372-82. PMCID: PMC3292623. (3MB PDF)

  • Bourne JN, Harris KM (2011) Coordination of size and number of excitatory and inhibitory synapses results in a balanced structural plasticity along mature hippocampal CA1 dendrites during LTP. Hippocampus, 21(4):354-73. PMCID: PMC2891364. (1.8MB PDF)

  • Shi B, Bourne J, Harris KM (2011) SynapticDB, effective web-based management and sharing of data from serial section electron microscopy. Neuroinformatics, 9:39–57. PMCID: PMC3063557. (3MB PDF)

  • Ivannikov MV, Harris KM, Macleod GT (2010) Mitochondria: enigmatic stewards of the synaptic vesicle reserve pool. Frontiers in Synaptic Neuroscience, 2:145. PMCID: PMC3059713. (800KB PDF)

  • Mishchenko Y, Hu T, Spacek J, Mendenhall J, Harris KM, Chklovskii DB (2010) Ultrastructural analysis of hippocampal neuropil from the connectomics perspective. Neuron, 67:1009-1020. (2MB PDF)

  • Kuwajima M, Harris KM (2010) GABAA receptor diversity revealed in freeze-fracture replica (Commentary on Kasugai et al.). European Journal of Neuroscience, 32:1866-1867. NIHMSID: NIHMS248941. (90KB PDF)

  • Witcher MR, Park YD, Lee MR, Sharma S, Harris KM, Kirov SA (2010) Three-dimensional relationships between perisynaptic astroglia and human hippocampal synapses. Glia, 58(5):572-87. PMCID: PMC2845925. (1.4MB PDF)

  • Jain V, Bollmann B, Richardson M, Berger DR, Helmstaedter MN, Briggman KL, Denk W, Bowden JB, Mendenhall JM, Abraham WC, Harris KM, Kasthuri N, Hayworth KJ, Schalek R, Tapia JC, Lichtman JW, Seung HS (2010) Boundary learning by optimization with topological constraints. Proceedings of the IEEE 23rd Conference on Computer Vision and Pattern Recognition (CVPR '10). (2MB PDF)

  • Jacobs G, Claiborne B, Harris KM (2010) Reconstruction of Neuronal Morphology. In: De Schutter (Ed) Computational Modeling Methods for Neuroscientists. The MIT Press, Cambridge. (3MB PDF)

2005-2009

  • Routh BN, Johnston D, Harris KM, and Chitwood RA (2009) Anatomical and Electrophysiological Comparison of CA1 Pyramidal Neurons of the Rat and Mouse. J Neurophysiol, 102: 2288–2302. PMCID: PMC2775381. (3MB PDF)

  • Fiala JC, Spacek J and Harris KM (2008) Dendrite Structure. In: Stuart et al. (Eds) Dendrites. 2nd Edition, Oxford University Press, Oxford UK. (12MB PDF)

  • Harris, KM (2008) Diversity in synapse structure and composition. In: Hell & Ehlers (Eds) Structural and Functional Organization of the Synapse. Springer. (7MB PDF)

  • Bourne JN, Harris KM. (2008) Balancing structure and function at hippocampal dendritic spines. Annu Rev Neurosci. 31:47-67. PMCID: PMC2561948. (0.4MB PDF)

  • Bourne J and Harris KM (2007) Do thin spines learn to be mushroom spines that remember? Curr Opin Neurobiol 17:381-386. (1.5MB PDF)

  • Witcher MR, Kirov SA, and Harris KM (2007) Plasticity of perisynaptic astroglia during synaptogenesis in the mature rat hippocampus. Glia 55:13-23. (0.7MB PDF)

  • Bourne JN, Sorra KE, Hurlburt J, and Harris KM (2007) Polyribosomes are increased in spines of CA1 dendrites 2 h after the induction of LTP in mature rat hippocampal slices. Hippocampus 17:1-4. (0.4MB PDF)

  • Bourne JN, Kirov SA, Sorra KE, and Harris KM (2007) Warmer preparation of hippocampal slices prevents synapse proliferation that might obscure LTP-related structural plasticity. Neuropharmacol 52:55-59. (0.4MB PDF)

  • Harris KM, Perry E, Bourne J, Feinberg M, Ostroff L, and Hurlburt J (2006) Uniform serial sectioning for transmission electron microscopy. J Neurosci 26(47):12101-12103. (0.2MB PDF)

  • Park M, Salgado JM, Ostroff L, Helton TD, Robinson CG, Harris KM, and Ehlers M (2006) Plasticity-induced growth of dendritic spines by Exocytic trafficking from recycling endosomes. Neuron 52:817-830. PMCID: PMC1899130. (2.3MB PDF)

  • Commentaries on Park et al.:
    • Kopec C and Malinow R (2006) Matters of size. Science 314(5805):1554-1555. (300KB PDF)
    • Halpain S (2006) They're plastic, but they recycle. Neuron 52:746-748. (60KB PDF)

  • Sorra KE, Mishra A, Kirov SA, and Harris KM (2006) Dense core vesicles resemble active-zone transport vesicles and are diminished following synaptogenesis in mature hippocampal slices. Neuroscience 141:2097-2106. (0.8MB PDF)

  • Petrak LJ, Harris KM and Kirov SA (2005) Synaptogenesis on Mature Hippocampal Dendrites occurs via Filopodia and Immature Spines during Blocked Synaptic Transmission. J. Comp. Neurology 484:183-190. (0.4MB PDF)

  • Fiala JC (2005) Reconstruct: A free editor for serial section microscopy. J Microscopy 218:52-61 (0.3MB PDF)

  • Seid MA, Harris KM and Traniello JFA (2005) Age-related changes in the number and structure of synapses in the lip region of the mushroom bodies in the ant Pheidole dentata.  J Comp Neurol  488:269-277. (0.5MB PDF)

2000-2004

  • Harris KM (2004) Dendritic Spines. Encyclopedia of Neuroscience, 3rd Edition. G. Adelman and B. Smith Editors. (0.4MB PDF).

  • Spacek J and Harris KM (2004) Trans-endocytosis via Spinules in Adult Rat Hippocampus. J Neuroscience 24(17):4233-41; and featured in This week in the journal. (1.2MB PDF)

  • Kirov SA, Petrak LJ, Fiala JC, Harris KM (2004) Dendritic spines disappear with chilling but proliferate excessively upon rewarming of mature hippocampus. Neuroscience 127(1):69-80. (0.8MB PDF)

  • Kirov SA, Goddard CA, and Harris KM (2004) Age-dependence in the homeostatic upregulation of hippocampal dendritic spine number during blocked synaptic transmission.  Neuropharmacology 47(5):640-8. (0.4MB PDF)

  • Fiala JC, Kirov SA, Feinberg MD, Petrak LJ, Goddard CA, George P and Harris KM (2003) Timing of Neuronal and Glial Ultrastructure Disruption During Brain Slice Preparation and Recovery During Incubation In Vitro. J Comp Neurol. 465(1):90-103.  (1MB PDF)

  • Harris KM, Fiala JC, Ostroff L. (2003) Structural changes at dendritic spine synapses during long-term potentiation. Philos Trans R Soc Lond B Biol Sci. 358:745-8. PMCID: PMC1693146. (2.8MB PDF)

  • Harris, KM. (2003) Dendritic Spines. Encyclopedia of Neuroscience, 3rd Edition. Ed. G. Adelman and B. Smith. Amsterdam; New York: Elsevier. (0.2MB PDF)

  • Henze DA, McMahon DB, Harris KM, Barrionuevo G (2002) Giant miniature EPSCs at the hippocampal mossy fiber to CA3 pyramidal cell synapse are monoquantal. J Neurophysiol. 87(1):15-29. (0.5MB PDF)

  • Fiala JC, Harris KM (2002) Computer-based alignment and reconstruction of serial sections. Microscopy and Analysis. USA Edition. 52:5-7. (3.5MB PDF)

  • Cooney JR, Hurlburt JL, Selig DK, Harris KM, Fiala JC (2002) Endosomal compartments serve multiple hippocampal dendritic spines from a widespread rather than a local store of recycling membrane. J Neurosci 22:2215-2224. (0.7MB PDF)

  • Fiala JC, Allwardt B, Harris KM (2002) Dendritic spines do not split during hippocampus LTP or maturation. Nat Neurosci 5:297-298. (0.3MB PDF)

  • Fiala JC, Spacek J, Harris KM (2002) Dendritic spine pathology: Cause or consequence of neurological disorders? Brain Research Reviews 39:29-54. (2MB PDF)

  • Ostroff LE, Fiala JC, Allwardt B, Harris KM (2002) Polyribosomes redistribute from dendritic shafts into spines with enlarged synapses during LTP in developing rat hippocampal slices. Neuron 35:535-545. (0.5MB PDF)

  • Fiala JC, Harris KM (2001) Extending unbiased stereology of brain ultrastructure to three-dimensional volumes. Journal of the American Medical Informatics Association. 8(1):1-16. (1.4MB PDF) PMCID: PMC134588.

  • Fiala JC, Harris KM (2001) Cylindrical diameters method for calibrating section thickness in serial electron microscopy. J Microscopy 202(3):468-472. (0.2MB PDF)

  • Feinberg MD, Szumowski KM, Harris KM (2001) Microwave fixation of rat hippocampal slices. In: RT Giberson, RS DeMaree Jr. (eds.) Microwave Techniques and Protocols. Humana Press: Totowa, New Jersey. pp. 75-88. (2MB PDF)

  • Xu-Friedman MA, Harris KM, Regehr WG (2001) Three-dimensional comparison of ultrastructural characteristics at depressing and facilitating synapses onto cerebellar Purkinje cells. J Neuroscience 21(17):6666-6672. (2MB PDF)

  • Sorra KE, Harris KM (2000) Overview on the structure, composition, function, development, and plasticity of hippocampal dendritic spines. Hippocampus 10(5):501-511. (0.6MB PDF)

  • Eichenbaum H and Harris KM (2000) Toying with memory in the hippocampus. Nature Neuroscience 3:205-206. (0.1MB PDF)

1995-1999

  • Kirov SA, Sorra KE, Harris KM (1999) Slices have more synapses than perfusion-fixed hippocampus from both young and mature rats. J Neuroscience 19(8):2876-2886. (1.4MB PDF)

  • Harris KM (1999) Structure, development, and plasticity of dendritic spines. Current Opinion in Neurobiology 9:343-348. (1.3MB PDF)

  • Fiala JC, Harris KM (1999) Dendrite Structure. In: G Stuart, N Spruston, M Häusser, (eds.) Dendrites. Oxford University Press: Oxford UK. (2.6MB PDF)

  • Ventura R, Harris KM (1999) Three-dimensional relationships between hippocampal synapses and astrocytes. J Neuroscience 19(16):6897-6906. (0.9MB PDF)

  • Kirov SA, Harris KM (1999) Dendrites are more spiny on mature hippocampal neurons when synapses are inactivated. Nature Neuroscience 2(10):878-883. (0.6MB PDF)

  • Harris, KM (1999) Calcium from internal stores modifies dendritic spine shape. Proc. Natl. Acad. Sci. 96:12213-12215. PMCID: PMC34250. (0.4MB PDF)

  • Spacek J, Harris KM (1998) Three-dimensional organization of cell adhesion junctions at synapses and dendritic spines in area CA1 of the rat hippocampus. J. Comp. Neurol. 393:58-68.  (0.9MB PDF)

  • Harris KM (1998) Dendritic Spines. Encyclopedia of Life Sciences. Macmillian Reference Ltd, London.

  • Fiala JC, Feinberg M, Popov V, Harris KM (1998) Synaptogenesis via dendritic filopodia in developing hippocampal area CA1. J. Neurosci. 18:8900-8911. (1.1MB PDF)

  • Shepherd GMG, Harris KM (1998) Three-dimensional structure and composition of CA3-->CA1 axons in rat hippocampal slices: implications for presynaptic connectivity and compartmentalization. J. Neurosci. 18:8300-8310. (1MB PDF)

  • Sorra KE, Fiala JC, Harris KM (1998) Critical assessment of the involvement of perforations, spinules, and spine branching in hippocampal synapse formation. J. Comp. Neurol. 398:225-240. (1.6MB PDF)

  • Sorra KE, Harris KM (1998) Stability in synapse number and size at 2 hr after long-term potentiation in hippocampal area CA1. J. Neurosci. 18:658-671. (1.4MB PDF)

  • Finkbeiner S, Tavazoie SF, Maloratsky A, Jacobs KM, Harris KM, Greenberg ME (1997) CREB: a major mediator of neuronal neurotrophin responses. Neuron 19:1031-1047.  (0.5MB PDF)

  • Ouyang Y, Kantor D, Harris KM, Schuman EM, Kennedy MB (1997) Visualization of the distribution of autophosphorylated Calcium/ Calmodulin-dependent protein kinase II after tetanic stimulation in the CA1 area of the hippocampus. J. Neurosci. 17:5416-5427. (1.6MB PDF)

  • Spacek J, Harris KM (1997) Three-dimensional organization of smooth endoplasmic reticulum in hippocampal CA1 dendrites and dendritic spines of the immature and mature rat. J. Neurosci. 17:190-203. (2.6MB PDF)

  • Lieberman AR, Spacek J (1997) Filamentous contacts: the ultrastructure and three-dimensional organization of specialized non-synaptic interneuronal appositions in thalamic relay nuclei. Cell Tiss. Res. 288:43-57.  (4.7MB PDF)

  • Harris KM (1996) Dendritic Spines. Encyclopedia of Neuroscience, 2nd Edition. G. Adelman and B. Smith Editors. (2.8MB PDF)

  • Harris KM (1995) How multiple-synapse boutons could preserve input specificity during an interneuronal spread of LTP. Trends. Neurosci. 18:365-369. (2.6MB PDF)

  • Harris KM, Sultan P (1995) Variation in number, location, and size of synaptic vesicles provides an anatomical basis for the non-uniform probability of release at hippocampal CA1 synapses. J. Neuropharmacology 34:1387-1395. (3.3MB PDF)

1990-1994

  • Carlbom I, Terzopoulos D, Harris KM (1994) Computer-assisted registration, segmentation, and 3D reconstruction from images of neuronal tissue sections. IEEE Transaction of Medical Imaging 13(2):351. (11MB PDF)

  • Harris KM, Kater SB (1994) Dendritic spines: Cellular specializations imparting both stability and flexibility to synaptic function. Annu. Rev. Neurosci.17:341-371. (2MB PDF)

  • Harris KM (1994) Serial electron microscopy as an alternative or complement to confocal microscopy for the study of synapses and dendritic spines in the central nervous system. In: Three-dimensional confocal microscopy: volume investigation of biological specimens (Stevens JK, Mills LR, Trogadis JE eds), pp 421-445. New York: Academic Press, Inc. (5MB PDF)

  • Lisman J, Harris KM (1994) Who's been nibbling on my PSD: Is it LTD? J. Physiol. (Paris) 88:193-195. (3.7MB PDF)

  • Harris KM, Rosenberg PA (1993) Localization of synapses in rat cortical cultures. Neuroscience 53(2):495-508. (4.4MB PDF)

  • Jackson PS, Suppes T, Harris KM (1993) Stereotypical changes in the pattern and duration of long-term potentiation at postnatal days 11 and 15 in the rat hippocampus. J. Neurophysiol. 70:1412-1419. (1.6MB PDF)

  • Lisman J, Harris KM (1993) Quantal analysis and synaptic anatomy - integrating two views of hippocampal plasticity. Trends Neurosci.16:141-147. (1.8MB PDF)

  • Sorra KE, Harris KM (1993) Occurrence and three-dimensional structure of multiple synapses between individual radiatum axons and their target pyramidal cells in hippocampal area CA1. J. Neurosci. 13:3736-3748.  (4.8MB PDF)

  • Chicurel ME, Harris KM (1992) Three-dimensional analysis of the structure and composition of CA3 branched dendritic spines and their synaptic relationships with mossy fiber boutons in the rat hippocampus. J. Comp. Neurol. 325:169-182. (4.2MB PDF)

  • Harris KM, Jensen FE, Tsao B (1992) Three-dimensional structure of dendritic spines and synapses in rat hippocampus (CA1) at postnatal day 15 and adult ages: Implications for the maturation of synaptic physiology and long-term potentiation. J. Neurosci. 12:2685-2705. (6.8MB PDF)

  • Carlbom I, Terzopoulos D. and Harris KM. (1991) Reconstructing and visualizing models of neuronal dendrites. In: Patrikalakis, NM (Ed.) Scientific Visualization of Physical Phenomena. Springer-Verlag, New York. (4.2MB PDF)

1985-1989

  • Harris KM, Jensen FE, Tsao B (1989) Ultrastructure, development, and plasticity of dendritic spine synapses in area CA1 of the rat hippocampus: Extending our vision with serial electron microscopy and three-dimensional analyses. In: The Hippocampus - New Vistas, Neurology and Neurobiology Volume 52 (Chan-Palay V, Kohler C eds), pp 33-52. New York: Alan R. Liss. (3.1MB PDF)

  • Harris KM, Stevens JK (1989) Dendritic spines of CA1 pyramidal cells in the rat hippocampus: serial electron microscopy with reference to their biophysical characteristics. J. Neurosci. 9:2982-2997. (1.9MB PDF)

  • Jensen FE, Harris KM (1989) Preservation of neuronal ultrastructure in hippocampal slices using rapid microwave-enhanced fixation. J. Neurosci. Methods. 29:217-230. (4.2MB PDF)

  • Teyler TJ, Perkins AT4, Harris KM (1989) The development of long-term potentiation in hippocampus and neocortex. Neuropsychologia. 27:31-39.  (6MB PDF)

  • Harris KM, Stevens JK (1988) Dendritic spines of rat cerebellar Purkinje cells: Serial electron microscopy with reference to their biophysical characteristics. J. Neurosci. 8:4455-4469. (2.2MB PDF)

  • Harris KM, Stevens JK (1988) Study of dendritic spines by serial electron microscopy and three-dimensional reconstructions. In: Intrinsic determinants of neuronal form and function. Neurology and Neurobiology Volume 37 (Lasek RJ, Black MM eds), pp 179-199. New York: Alan R. Liss. (2.7MB PDF)

  • Harris KM, Landis DM (1986) Membrane structure at synaptic junctions in area CA1 of the rat hippocampus. Neurosci. 19:857-872. (3.8MB PDF)

  • Harris KM, Marshall PE, Landis DM (1985) Ultrastructural study of cholecystokinin-immunoreactive cells and processes in area CA1 of the rat hippocampus. J. Comp. Neurol. 233:147-158. (4MB PDF)

1980-1985

  • Harris KM, Teyler TJ (1984) Developmental onset of long-term potentiation in area CA1 of the rat hippocampus. J. Physiol. (Lond.) 346:27-48. PMCID: PMC1199482. (3MB PDF)

  • Harris KM, Teyler TJ (1983) Age differences in a circadian influence on hippocampal LTP. Brain Res. 261:69-73. (0.6MB PDF)

  • Harris KM, Teyler TJ (1983) Evidence for late development of inhibition in area CA1 of the rat hippocampus. Brain Res. 268:339-343. (0.6MB PDF)

  • Harris KM, Cruce WLR, Greenough WT, Teyler TJ (1980) A Golgi impregnation technique for thin brain slices maintained in vitro. J. Neurosci. Methods. 2:363-371. (2.5MB PDF)

  • Harris KM (1980) Relationships between dendrite and spine neck diameters in freeze-fractured rat hippocampal formation. Biol. Bull. 159:470-471. (1.7MB PDF)