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This is how we make up our embedding media for serial sectioning. 

PB Fixatives

Protocol
Final Volume
Chemicals Volume to Add Stock Solutions (% or mM) Final Concentrations (% or mM)
PB Fixtive: 3.5% Para/0.0% Glut
Final Volume: 10
Glutaraldehyde 0 70.0% 0.0%
- Paraformaldehyde 3.5 10.0% 3.5%
- CaCl2 0 1000 0
- MgSO4 0 2000 0
- Phosephate Buffer 5 200 100
- H2O 1.5 0 0
PB Fixtive: 3.5% Para/0.1% Glut
Final Volume: 10
Glutaraldehyde 0.014285714 70.0% 0.1%
- Paraformaldehyde 3.5 10.0% 3.5%
- CaCl2 0 1000 0
- MgSO4 0 2000 0
- Phosephate Buffer 5 200 100
- H2O 1.485714286 0 0
PB Fixtive: 3.5% Para/0.2% Glut
Final Volume: 10
Glutaraldehyde 0.028571429 70.0% 0.2%
- Paraformaldehyde 3.5 10.0% 3.5%
- CaCl2 0 1000 0
- MgSO4 0 2000 0
- Phosephate Buffer 5 200 100
- H2O 1.471428571 0 0
PB Fixtive: 3.25% Para/0.5% Glut
Final Volume: 10
Glutaraldehyde 0.071428571 70.0% 0.5%
- Paraformaldehyde 3.25 10.0% 3.3%
- CaCl2 0 1000 0
- MgSO4 0 2000 0
- Phosephate Buffer 5 200 100
- H2O 1.678571429 0 0
Phend, Rustoni, Weinberg - like Fixtive:
1% Para/2.5% Glut/0.1% Picric Acid

Final Volume: 40
Glutaraldehyde 1.428571429 70.0% 2.5%
- Paraformaldehyde 4 10.0% 1.0%
- Picric Acid 3.076923077 1.3% 0.1%
- Phosephate Buffer 20 200 100
- H2O 11.4950549 0 0
Picric Acid Fix (0.05% , 0.2% Picric Acid)
- Sonicate if frozen

Final Volume: 100
Glutaraldehyde 0.071428571 70.0% 0.05%
- Paraformaldehyde 40 10.0% 4.0%
- Picric Acid 15.38461538 1.3% 0.2%
- Phosephate Buffer 25 400 100
- H2O 19.54395604 0 0
Picric Acid Fix (0.1% , 0.2% Picric Acid)
- Sonicate if frozen

Final Volume: 100
Glutaraldehyde 0.142857143 70.0% 0.10%
- Paraformaldehyde 40 10.0% 4.0%
- Picric Acid 15.38461538 1.3% 0.2%
- Phosephate Buffer 50 200 100
- H2O -5.52747 0 0
Picric Acid Fix (0.5% , 0.2% Picric Acid)
- Sonicate if frozen

Final Volume: 20
Glutaraldehyde 0.142857143 70.0% 0.5%
- Paraformaldehyde 8 10.0% 4.0%
- Picric Acid 3.076923077 1.3% 0.2%
- Phosephate Buffer 5 400 100
- H2O 3.78021978 0 0

Last Updated: 09/18/2007