Table of Contents
Anatomical Projections
Axonal Transport of Radioactively Labeled amino acid such as proline
Normal Ocular Dominance Columns in Visual Cortex in Macque Monkey
Monocular deprivation in kitten
Non-deprived eye captures more of Visual Cortex
Axonal branching expansion as basis of ocular dominance stripe widening
Synaptotrophic Hypothesis
Neurotrophins and their receptors - revised 4/17/2001
Specific Neurotrophins are responsible for specific connections
Specific Neurotrophins are responsible for specific connections
Specific Neurotrophins are responsible for specific connections
Specific localization of BDNF and NT3 to different cortical layers provides further specificity
Predictions of the Synaptotrophic Hypothesis
Infusion of NTs - Kitten Visual cortex
Infusion of NTs - Kitten Visual cortex
Infusion of NTs - Kitten Visual cortex
Further evidence for BDNF role in regulating ocular dominance columns
Short-term Activity-dependent regulation of BDNF expression
BDNF regulates production of LTD/LTP in visual cortex
Summary NTs
Synapse Maintenance
IDEAS ABOUT MATURE SYNAPTOGENESIS VIA SPLITTING
Branched Spine
Different Heads Never Share the Same Axon
Branched Spine with Perforated PSDs
Long axons run between neighboring spines
How Spines are Formed
Remaining Questions for Future Research!
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