Anatomical Projections

5/1/01


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Table of Contents

Anatomical Projections

Axonal Transport of Radioactively Labeled amino acid such as proline

Normal Ocular Dominance Columns in Visual Cortex in Macque Monkey

Monocular deprivation in kitten

Non-deprived eye captures more of Visual Cortex

Axonal branching expansion as basis of ocular dominance stripe widening

Synaptotrophic Hypothesis

Neurotrophins and their receptors - revised 4/17/2001

Specific Neurotrophins are responsible for specific connections

Specific Neurotrophins are responsible for specific connections

Specific Neurotrophins are responsible for specific connections

Specific localization of BDNF and NT3 to different cortical layers provides further specificity

Predictions of the Synaptotrophic Hypothesis

Infusion of NTs - Kitten Visual cortex

Infusion of NTs - Kitten Visual cortex

Infusion of NTs - Kitten Visual cortex

Further evidence for BDNF role in regulating ocular dominance columns

Short-term Activity-dependent regulation of BDNF expression

BDNF regulates production of LTD/LTP in visual cortex

Summary NTs

Synapse Maintenance

IDEAS ABOUT MATURE SYNAPTOGENESIS VIA SPLITTING

Branched Spine

Different Heads Never Share the Same Axon

Branched Spine with Perforated PSDs

Long axons run between neighboring spines

How Spines are Formed

Remaining Questions for Future Research!

Author: Kristen M. Harris