Table of Contents
Neurobiology of Synapses
Neurobiology of Synapses Course
Student Work Load
Grading
History
Neuron vs. Reticulum
Key Advocates/Adversaries
Age of Light Microscopy
by mid 19th century
1836-37
First Identified Neuron
Purkinje, students, Czech
"Axis Cylinder" Milestones
1853 - Kollicker
First Manual of Human Histology
1860's - Deiters
Chromic acid, Potassium Bicarbonate
Serial sections! or teasing out single cells
Support builds for Reticular Theory
The Revolutionary Method of Golgi
Introduced in 1873
Golgi Impregnation of Hippocampal Pyramidal Cell (1979, Harris)
Golgi's Contributions
Golgi's Speculations
Neuron Theory Begins to Take Form
Santiago Ramón y Cajal
Sherrington - A physiologist's Contribution to Neuron Doctrine
Cajal intensified Golgi's Stain
First paper on Bird brains 1888
Neuron Doctrine - Cajal 1889
Physiological corollaries of the Neuron doctrine
Golgi and Cajal share Nobel Prize - 1906
Cajal's Neuron Doctrine Nobel Lecture was Cajal at his best
Behind the scenes Cajal was
furious with Golgi for his
Etymology of "Synapse"
Sherrington - A physiologist's Contribution to Neuron Doctrine
Electron microscopy unequivocally validates the Neuron Doctrine
All of neuroscience is at some level
the study of synapses.
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